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Analysis of Glutathione Levels in the Brain Tissue Samples From HIV-1-positive Individuals and Subject With Alzheimers Disease and its Implication in the Pathophysiology of the Disease Process

The product inhibits NNMT activity, disrupts the metabolic balance of glioma cells, reduces energy supply, and thereby suppresses glioma cell proliferation and migration, serving as an important tool for metabolictargeted research of glioblastoma.In bladder cancer studies, NNMT has been identified as a major regulator of cell migration

The glutaminase encoded by GLS2 can be directly bound and transcriptionally induced by p53, reducing cellular sensitivity to ROS-associated apoptosis, possibly through glutathione-dependent antioxidant defense (Suzuki et al., 2010

USA 97, 1165511660

[DOI] [PubMed] [Google Scholar] 191.Fedyk ER, Wyant T, Yang LL, Csizmadia V, Burke K, Yang H, et al